1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，elsevier、ncbi电子期刊，springer link全文电子期刊，pubmed等检索资源上查阅关于两性离子以及聚乙酰亚胺稳定金属纳米颗粒的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

1） Branco de Barros, A. L., S. F. de Andrade, et al. (2013). "Radiolabeling of low molecular weight-galactose-based glycodendrimer with technetium-99m and biodistribution studies." Journal of Radioanalytical and Nuclear Chemistry 298(1): 605-609. 2） Cai, H., K. Li, et al. (2015). "Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors." Small 11(35): 4584-4593. 3） Guo, R., H. Wang, et al. (2011). "Enhanced X-ray attenuation property of dendrimer-entrapped gold nanoparticles complexed with diatrizoic acid." Journal of Materials Chemistry 21(13): 5120-5127. 4） Kovacs, L., M. Tassano, et al. (2014). "Labeling polyamidoamine (PAMAM) dendrimers with technetium-99m via hydrazinonicotinamide (HYNIC)." Current radiopharmaceuticals 7(2): 115-122. 5） Mizuhara, T., K. Saha, et al. (2015). "Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH." Angewandte Chemie-International Edition 54(22): 6567-6570. 6） Song, M., Z. Guo, et al. (2017). "Synthesis and preliminary evaluation of a Tc-99m-labeled folate-PAMAM dendrimer for FR imaging." Chemical Biology Drug Design 89(5): 755-761. 7） Wang, S., P. Huang, et al. (2016). "Stimuli-Responsive Programmed Specific Targeting in Nanomedicine." Acs Nano 10(3): 2991-2994. 8） Wen, S., K. Li, et al. (2013). "Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications." Biomaterials 34(5): 1570-1580. 9） Zhang, Y., Y. Sun, et al. (2010). "Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates." Journal of Medicinal Chemistry 53(8): 3262-3272. 10） Zhou, B., J. Yang, et al. (2016). "PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging." Colloids and Surfaces B-Biointerfaces 140: 489-496.

3. 毕业设计（论文）进程安排

2018.1.2-2018.1.19 文献查询和资料阅读 2018.1.19-2018.1.23 研究方案制定和开题报告写作 2018.1.24-2018.3.10 实践内容的准备 2018.3.11-2018.5.10 实践 2018.5.10-2018.5.15 实践内容处理与结果分析 2018.5.16-2018.6.1 毕业论文书写