1. 毕业设计（论文）的内容和要求

1.熟悉基本的实验操作，理解实验的基本内容；2.能做到流利阅读文献，掌握文献内容；3.熟练运用各种信息平台查阅相关信息；4.了解有机化学中关于水相合成反应的优缺点与经典方式的有缺点对比，以及亲核进攻反应和官能团转化反应的机理；5.熟悉并掌握利用柱层析法分离得到纯产物的方法。

2. 参考文献

[1]Tangqian Jiao,Jingxuan Tu,Gaoqiang Li,Feng Xu. Cu-catalyzed Asymmetric Henry Reaction Promoted by Chiral Camphor Schiff Bases. Journal of Molecular Catalysis. A, Chemical,2016,:. [2]Yong Zhang,Biao-Wen Wei,Li-Na Zou,Mei-Lian Kang,Hai-Qing Luo,Xiao-Lin Fan. ”On water” direct vinylogous Henry (nitroaldol) reactions of 3,5-dimethyl-4-nitroisoxazole with aldehydes and trifluoromethyl ketones. Tetrahedron,2016,:. [3]Bing Yi,Yanyan Yin,Ziqi Yi,Wei Zhou,Haitao Liu,Nianyuan Tan,Hai Yang. Dendronized Piperidine: Highly Effective and Recyclable Catalysts for Henry Reaction. Tetrahedron Letters,2016,:. [4]Keisuke Takada,Kazuo Nagasawa. Enantioselective Aza‐Henry Reaction with Acyclic Guanidine‐Thiourea Bifunctional Organocatalyst. Adv. Synth. Catal.,2009,3513:. [5]Kun Xu,Guoyin Lai,Zhenggen Zha,Susu Pan,Huanwen Chen,Zhiyong Wang. A Highly anti ‐Selective Asymmetric Henry Reaction Catalyzed by a Chiral Copper Complex: Applications to the Syntheses of ( )‐Spisulosine and a Pyrroloisoquinoline Derivative. Chem. Eur. J.,2012,1839:. [6]Pranjal P. Bora,Ghanashyam Bez. Henry Reaction in Aqueous Media at Neutral pH. Eur. J. Org. Chem.,2013,201314:. [7]Fei Liu,Shaohua Gou,Lei Li. Asymmetric Henry reactions of aldehydes with various nitroalkanes catalyzed by copper(II) complexes of novel chiral N ‐monoalkyl cyclohexane‐1,2‐diamines. Appl. Organometal. Chem.,2014,283:. [8]H. Atoholi Sema,Ghanashyam Bez,Sanjib Karmakar. Asymmetric Henry reaction catalysed by L‐proline derivatives in the presence of Cu(OAc)2: isolation and characterization of an in situ formed Cu(II) complex. Appl. Organometal. Chem.,2014,284:. [9]Xiaojuan Wang,Wenxian Zhao,Gaowei Li,Jin Wang,Guanjun Liu,Lantao Liu,Ruijuan Zhao,Mincan Wang. Enantioselective copper(II)‐catalyzed Henry reaction utilizing chiral aziridinyl alcohols. Appl. Organometal. Chem.,2014,2812:. [10]Luo Mei,Tang Hai Ming,Li Qian Rong,Sun Jie,Yang Shan Zhong,Li Xue Liang. The synthesis of N-Zn, N-Cu complexes involving 2-amino pyridine and ethylenediamine ligands and application to the Henry reaction. Journal of Chemical Sciences,2009,1214:.

3. 毕业设计（论文）进程安排

毕业设计进程安排: 2016.3.1 进入实验室，交待相关事宜，安排实验任务； 2016.3.1-2016.3.4 查阅文献，准备开题报告； 2016.3.10 提交开题报告。

2016.3.10-2016.3.31合成试验所需原料； 2016.4.1-2016.5.29选择相应的反应条件进行反应，筛选条件，优化反应条件；2016.5.30-2016.6.4 实验数据整理与分析。

2016.6.4-2016.6.10 撰写论文。