1. 毕业设计（论文）的内容和要求

石英毛细管经过硅烷偶联剂修饰后，在橡胶、塑料、催化剂、色谱柱、吸附剂、生物和医药等领域中具有独特的应用性能，功能化设计探讨了不同修饰方法可控性及对所形成的修饰层结构及稳定性的影响。

apts、mptes是非常重要的硅烷偶联剂。

经过功能化设计的石英毛细管内壁通过表面的活性氨基可以和多种无机离子或无机、有机、生物分子发生反应, 在生物化学、分析、催化、工业和电子学等领域具有广泛的应用前景。

2. 参考文献

[1]Stair JL, Hol combe J A. Microchemical Journal, 2005, 81: 69 ～80. [2]Wal carius A, Etienne M, Delacote C. Analytica Chimica Acta,2004, 508: 87 ～98. [3]Jal P K, Patel S, Mishra B K. Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions[J]. Talanta, 2004, 62(5): 1005～1028. [4] Wang Gang(王刚), Yan Feng(颜峰), Teng Zhaogang(滕兆刚), Yang Wensheng(杨文胜), Li Tiejin(李铁津). The surface modification of silica with APTS[J]. Progress in Chemistry(化学进展), 2006, 18(2/3):238～245. [5]Smith E A, Chen W. How to prevent the loss of surface functionality derived from aminosilanes[J]. Langmuir, 2008, 24(21): 12405～12409. [6]Aissaoui N, Bergaoui L, Landoulsi J, Lambert J F, Boujday S. Silane layers on silicon surfaces: mechanism of interaction, stability, and influence on protein adsorption[J]. Langmuir, 2012, 28(1): 656～665. [7]Kim J, Holinga G J, Somorjai G A. Curing induced structural reorganization and enhanced reactivity of amino-terminated organic thin films on solid substrates: observations of two types of chemically and structurally unique amino groups on the surface[J]. Langmuir,2011, 27(9): 5171～5175. [8] 陈凯玲,赵蕴慧,袁晓燕. 二氧化硅粒子的表面化学修饰#8212;#8212;#8212;方法、原理及应用[J]. 化学进展,3013,25(1):95～104. [9] 王梦兰，贾法龙，张礼知. 石英毛细管内壁镀金工艺的研究[J]. 表面技术,2015,44(2):8～13. [10] 闻艳艳.微流控芯片电化学葡萄糖检测方法研究[D].东北：东北大学，2008. [11] Nesrine Aissaoui,Latifa Bergaoui,Jessem Landoulsi etal. Silane Layers on Silicon Surfaces: Mechanism of Interaction, Stabilityand Influence on Protein Adsorption[J]. Langmuir, 2012, 28: 656～665. [12] Boujday, S.; Gu, C.; Girardot, M.; Salmain, M.; Pradier, C.-M.Surface IR applied to rapid and direct immunosensing of environmentalpollutants[J]. Talanta 2009, 78 (1), 165～170. [13] Boujday, S.; Nasri, S.; Salmain, M.; Pradier, C.-M. Surface IR immunosensors for label-free detection of benzo[a]p yrene[J]. Biosens.Bioelectron. 2010, 26 (4), 1750～1754. [14] Gooding, J. J.; Ciampi, S. The molecular level modification of surfaces: From self-assembled monolayers to complex molecular assemblies.Chem[J]. Soc. Rev. 2011,( 40) :2704～2718. [15] Kim, J.; Cho, J.; Seidler, P. M.; Kurland, N. E.; Yadavalli, V. K.Investigations of chemical modifications of amino-terminated organic films on silicon substrates and controlled protein immobilization[J].Langmuir,2010, 26 (4):2599～2608.

3. 毕业设计（论文）进程安排

2015.11.21-11.30 与导师会面，布置论文题目及要求 12.1-12.31 查阅资料，完成开题报告和任务书 2016.3.1-3.5 准备实验所需药品和器材 3.6-3.31 清洗方案确定和分析完成 4.1-5.1 偶联方案的确定和分析完成 5.1-5.31 数据整理，书写论文,制作PPT 6.1-6.10 准备论文答辩