1. 毕业设计（论文）的内容和要求

研制高效、低毒、低残留、环境友好的新农药是二十一世纪农药领域研究的主要目标。

而寻找作用机制新颖、独特的先导化合物，并进行结构改造不仅是获得具有自主知识产权新型农药的有效途径，也是解决抗性风险的关键所在。

氯虫酰胺作为苯胺甲酰类化合物的代表具有高效、低毒、作用机制独特的特点，因而成为本世纪初杀虫剂创制的热点。

2. 参考文献

1.Zhang Xiulan, Li Yuxin, Ma Jinlong, Zhu Hongwei, Wang Baolei, Mao Mingzhen, Xiong Lixia,Li Yongqiang, LiZhengming Synthesis and insecticidal evaluation of novel anthranilic diamidescontaining N-substitued nitrophenylpyrazole [J]. Bioorganic Medicinal Chemistry2014, 22: 186#8211;193. 2.Wang Baolei, Zhu Hongwei, Ma Yi, Xiong Lixia, Li Yongqiang, Zhao Yu, Zhang Jifeng,Chen Youwei, Zhou Sha, and Li Zhengming. Synthesis, insecticidal activities, and SAR studies of novel pyridylpyrazole acid derivatives based on amide bridge modification of anthranilic diamide insecticides [J]. Journal of Agricultural and Food Chemisrty 2013, 61(23): 5483-5493. 3.Chen Kai, Liu Qi, Ni Jueping, Zhu Hongjun, Li Yufeng, Wang Qiang. Synthesis, insecticidal activities, and SAR studies of novelanthranilicdiamidescontaining pyridylpyrazole-4-carboxamide [J].Pest Management Science, 2014.Accepted. Liu Qi, Chen Kai, Wang Qiang, Ni Jueping, Li Yufeng, Zhu Hongjun, Ding Yuan. Synthesis, insecticidal activity, structure#8211;activity relationship (SAR) and density functional theory (DFT) of novel anthranilicdiamides analogs containing 1,3,4-oxadiazole rings [J].RSC Advances, 2014, 4: 55445-55451.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 2015/12-2015/01 选题及确定任务 2016/01-2016/02 查资料，撰写开题报告 2016/02-2016/05 完成合成及生物活性测试 2016/05-2016/06 完成DFT计算 2016/06 撰写论文、完成答辩