1. 毕业设计（论文）的内容和要求

重金属汞是一种具有极强生理毒性的化学物质，由于其具有持久性、易迁移性和高度的生物富集性，使其成为目前全球最引人关注的环境污染物之一。

不同形态的汞，其毒性和环境行为是不同的，无机汞在生物体内会转变成有机汞， 有机汞是各种形态的汞中毒性最大的，其中以甲基汞最为常见，其毒性是无机汞的几百倍，并能由无机汞在自然界中通过生物甲基化和非生物甲基化而形成。

同时汞离子对人体含有s原子的配合基显现出了很强的亲和力，能引起蛋白质、酶和膜的巯基(-sh)块结从而造成人体组织受损。

2. 参考文献

[1] Lin Yuan, Weiying Lin,* Kaibo Zheng, Longwei He and Weimin Huang. Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging[J]. Chem. Soc. Rev., 2013, 42: 622--661. [2] Guang-Jie Song, Su-Yun Bai, Xi Dai, Xiao-Qun Cao. A ratiometric lysosomal pH probe based on the imidazo[1,5-a]pyridine#8211;rhodamine FRET and ICT system[J]. RSC Adv., 2016, 6: 41317 - 41322. [3] Carlo Santini, Maura Pellei, Valentina Gandin. Advances in Copper Complexes as Anticancer Agents[J]. Chem. Rev., 2014, 114: 815#8722;862. [4] Rosario Mart, Fabiola Zapata, Antonio Caballero, Arturo Espinosa. 2-Aza-1,3-butadiene Derivatives Featuring an Anthracene or Pyrene Unit: Highly Selective Colorimetric and Fluorescent Signaling of Cu2 Cation[J]. Org. Lett., 2006, 15: 3234-3238. [5] Xiaohua Li, Xinghui Gao, Wen Shi, and Huimin Ma. Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes[J]. Chem. Rev., 2014, 114: 590#8722;659. [6] Hisataka Kobayashi, Mikako Ogawa, Raphael Alford. New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging[J]. Chem. Rev., 2010, 110: 2620#8211;2640. [7] Yuming Yang, Qiang Zhao, Wei Feng, and Fuyou Li. Luminescent Chemodosimeters for Bioimaging[J]. Chem. Rev., 2013, 113: 192#8722;270. [8] Qian Liu, Juanjuan Peng, Lining Sun, and Fuyou Li. High-Efficiency Upconversion Luminescent Sensing and Bioimaging of Hg(II) by Chromophoric Ruthenium Complex -Assembled Nanophosphors[J]. ACS NANO, 2011, 10: 8040-8048. [9] Lin Yuan, Weiying Lin, Kaibo Zheng, and Sasa Zhu. FRET-Based Small-Molecule Fluorescent Probes: Rational Design and Bioimaging Applications[J]. Accounts of Chemcial Research, 2012, 17. [10] Ramon Martnez-Manez, Felix Sancenon. Fluorogenic and Chromogenic Chemosensors and Reagents for Anions[J]. Chemical Reviews, 2003, 103. 4420-4473. [11] Duong Tuan Quang, Jong Seung Kim. Fluoro and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and Biospecimens[J]. Chem. Rev., 2010, 110: 6280#8211;6301. [12] Kyle P. Carter, Alexandra M. Young, and Amy E. Palmer. Fluorescent Sensors for Measuring Metal Ions in Living Systems[J]. Chem. Rev., 2013. [13] Lin Yuan, Weiying Lin, Zengmei Cao, Jiaoliang Wang, and Bin Chen. Development of FRET-Based Dual-Excitation Ratiometric Fluorescent pH Probes and Their Photocaged Derivatives[J]. Chem. Eur. J., 2012, 18: 1247-1255. [14] Young Hoon Lee, Min Hee Lee, Jun Feng Zhang, and Jong Seung Kim. Pyrene Excimer-Based Calix [4] arene FRET Chemosensor for Mercury(II)[J]. J. Org. Chem., 2010, 75: 7159-7165. [15] M. Dela Cruz-Guzmana, A. Aguilar. Hybrid Porous Silicon- Rhodamine B Derivative Nanostructures as Chemical Sensor for Hg (II) Detection[J]. ECS Transactions, 2014, 64: 31-34. [16] Xiao-Wei Liu, Tian-Jun Sun, Jiang-Liang Huab and Shu-Dong Wang. Composites of metal-organic frameworks and carbon-based materials: preparations, functionalities and applications[J]. J. Mater. Chem. A, 2016, 4: 3584-3616. [17] Zhiqiang Zhu, Yuanyuan Su, Jiang Li, Di Li, Jiong Zhang, Shiping Song, Yun Zhao. Highly Sensitive Electrochemical Sensor for Mercury (II) Ions by Using a Mercury-Specific Oligon- ucleotide Probe and Gold Nanoparticle-Based Amplification[J]. Analytical Chemistry, 2009, 81: 7660-7666. [18] Ha Na Kim, Min Hee Lee, Hyun Jung Kim.A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions[J]. Chem. Soc. Rev., 2008, 37: 1465-1472. [19] Supriti Sen, Sandipan Sarkar, Basab Chattopadhyay. A ratiometric fluorescent chemosensor for iron: discrimination of Fe2 and Fe3 and living cell application[J]. Analyst, 2012, 137: 3335-3342.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 2017.1.2-2017.3.1 查阅资料，完成开题报告和任务书 2017.3.2-2017.3.10 确定方案，学习实验过程和操作 2017.3.11-2017.4.30 独立实验，合成产品并进行结构表征 2017.5.1-2017.5.30 数据整理，书写论文，制作PPT 2017.5.30- 修改论文并完成答辩