1. 毕业设计（论文）的内容和要求

荧光探针分析具有灵敏度高、选择性好、能够实现开关操作等优点，是分析化学学科研究的热点之一。

罗丹明类为一种价廉易得的荧光染料，在水相中能稳定产生极强的红色荧光，且具有较大的摩尔吸光系数及相对较长的吸收波长和荧光发射波长。

在碱性条件下，罗丹明类化合物能形成具有内酰胺的螺环结构，为无吸收且无荧光类化合物。

2. 参考文献

[1]刘卫敏，光化学传感器的设计，合成及其识别性能研究。

中国科学院理化技术研究所，2008。

[2]zhang j.f,zhou y,yoon j.naphthalimide modified rhodamine derivative:ratiometric and selective fluorescent sensor for cu2 based on two different approaches[j].org lett., 2010, 12 (17):3852-3855. [3]delacruz j.l,blanchard g.j.the influence of chromo phore structure on intermolecular interaction.a study of selected rhodamines in polar protic and aprotic solvents [j]. j phys chem.a.2002,106(44):10718-10724. [4]ghanadzadeh a.,zanjanchi m.a.self-assocoation of rhodamine dyes in different host materials [j],spectrochimica acta part a,2001,57(9):1865-1871. [5]sando s.,hiroshi a.,kool. quenched auto-ligating dnas:multicolor identification of nucleic acids at single nucleotide resolution[j].j.am.chem.soc.,2004,126:1081-1087. [6]quang, d. t.; kim, j. s. fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens[j].chem. rev. 2010, 110(10), 6280-6310. [7]y.yang,q.zhao,w.feng and f.y.li,luminescent chemodosimeters for bioimaging[j]. chem rev, 2013, 113, 192 [8]chunwei yu,ying wang,ke xu.characterization of a highly cu2 -selective fluorescent probe derived from rhodamine b[j].dyes pigm,2013,96,38. [9]j pan,p zhan,m hu.a fluorescent rationmetric chemodosimeter for cu2 based on tbet and its application in living cells[j].org lett.,2013,15,492 [10]m kumar,n kumar,v.bhalla.highly selective fluorescence turn-on chemodosimeter based on rhodamine for nanomolar detection of copper ions[j].org lett.,2012,14,406 [11]j liu,c li,f li.fluorescence turn-on chemodosimeter-functionalized mesoporous silca nano- particles and their application in cell imaging[j].j.mater.chem.,2011,21,7175. [12]puhui xie,fengqi guo,dan li.a cu2 chemodosimeter based on amplified fluorescence in the red region[j].j.lumin.,2011,131,104. [13]d wang,y shiraishi,t hirai.a bodipy-based fluorescent chemodosimeter for cu(ii) driven by an oxidative dehydrogenation mechanism[j].chem,commun.,2011,47,2673. [14]wy liu,hy li,bx zhao.synthesis,crystal structure and living cell imaging of a cu2 - specific molecular probe[j].org,biomol.chem.,2011,9,4802. [15]c yu,j zhang,r wang.highly sensitive and selective colorimetric and off-on fluorescent probe for cu2 based on rhodamine derivative[j].org,biomol.chem.,2011,9,4802. [16]v dujols,f ford,aw czarnik.a long-wavelength fluorescent chemodosimeter selective for cu(ii) ion in water[j].j.am.chem.soc.,1997,119,7386.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 2017.1.2-2017.3.1 查阅资料，完成开题报告和任务书 2017.3.2-2017.3.10 确定方案，学习实验过程和操作 2017.3.11-2017.4.30 独立实验，合成产品并进行结构表征 2017.5.1-2017.5.30 数据整理，书写论文，制作PPT 2017.5.30- 修改论文并完成答辩