1. 毕业设计（论文）的内容和要求

1.熟悉基本的实验操作，理解实验的基本内容； 2.能做做到流利阅读文献， 掌握文献内容； 3.熟练运用各种信息平台查阅相关信息； 4.了解当下有机化学方 向中 C-H 键活化的内容，了解 C-H 键活化的背景以及意义； 5.熟悉并掌握 C-H 键活化的机理。

2. 参考文献

[1] Sun, S.; Shang, M.; Wang, H.; Lin, H.; Dai, H.； Yu, J. Cu(II)-Mediated C(sp2)-H Hydroxylation. J. Org. Chem. 2015, 80, 8843-8848. [2] Wang, H.; Shang, M.; Sun, S.; Zhou, Z.; N.Laforteza, B.; Dai, H.; Yu, J. Cu(II)-Catalyzed Coupling of Aromatic C-H Bonds with Malonates. Org. Lett. 2015, 17, 1228-1231. [3] Zhang, J.; Chen, H.; Lin, C.; Liu, Z.; Wang, C.; Zhang, Y. Cobalt-Catalyzed Cyclization of Aliphatic Amides and Terminal Alkynes with Silver-Cocatalyst. J. Am. Chem. Soc. 2015, 137, 12990-12996. [4] Shi, J.; Zhang, J.; Wang, B.; Hu, P.; Zhao, K.; Shi, Z. Fe-Promoted Chlorobenzylation of Terminal Alkynes through Benzylic C(sp3)#8722;H Bond Functionalization. Org. Lett. 2016, 18, 1238-1241. [5] Zhang, Z.; Liu, B.; Wang, C.; Shi, B. Cobalt(III)-Catalyzed C2-Selective C-H Alkynylation of Indoles. Org. Lett. 2015, 17, 4094-4097. [6] Yang, L.; Rong, Z.; Wang, Y.; Tan, Z.; Wang, M.; Zhao, Y. Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5 4] Cycloaddition. Angew. Chem. Int. Ed. 2017, 56, 1-6. [7] Kong, W.; Wang, Q.; Zhu, J. Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient s-Alkylpalladium(II) Complex. Angew. Chem. Int. Ed. 2016, 55, 1-6. [8] Kubota, A.; H. Emmert, M.; S. Sanford, M. Pyridine Ligands as Promoters in Pd II/0 -Catalyzed C-H Olefination Reactions. Org. Lett. 2012, 14, 1760-1763. [9] Lin, C.; Li, D.; Wang, B.; Yao, J.; Zhang, Y. Direct ortho-Thiolation of Arenes and Alkenes by Nickel Catalysis. Org. Lett. 2015, 17, 1328-1331. [10]Li, Z.; Sheng, J.; Zhang, Y.; Li, X.; Xu, Y. Role of CeO2 as oxygen promoter in the accelerated photocatalytic degradation of phenol over rutile TiO2. Applied Catalysis B: Environmental. 2015, 166, 313#8211;319. [11]Shen, P.; Wang, X.; Wang, P.; Zhu, R.; Yu, J. Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene. J. Am. Chem. Soc. 2015, 137 11574-11577. [12]Liu, Y.; Xu, H.; Kong, W.; Shang, M.; Dai, H.; Yu, J. Overcoming the limitations of directed C#8211;H functionalizations of heterocycles. Nature. 2014, 515, 389-393. [13]He, J.; Jiang, H.; Takise, R.; Zhu, R.; Chen, G.; Dai, H.; Dhar, T.; Shi, J.; Zhang, H.; Cheng, P.; Yu, J. Ligand-Promoted Borylation of C(sp3)-H Bonds with Palladium(II) Catalysts. Angew. Chem. Int. Ed. 2016, 55, 785-789. [14]Liu, T.; Mei, T.; Yu, J. γ,δ,ε-C(sp3)-H Functionalization through Directed Radical H-Abstraction. J. Am. Chem. Soc. 2015, 137, 5871-5874. [15]Xu, H.; Shang, M.; Dai, H.; Yu, J. Ligand-Controlled Para-Selective C-H Arylation of Monosubstituted Arenes. Org. Lett. 2015, 17, 3830-3833.

3. 毕业设计（论文）进程安排

2016.12 进入实验室，交待相关事宜，熟悉实验操作，安排实验任务 2017.2-2017.3 查阅文献，准备开题报告 2017.3.3 提交开题报告 2017.3-2017.4 合成试验所需原料 2017.4-2017.6 选择相应的催化剂催化反应进行，筛选条件，优化反应条件 2017.5-2017.6 实验数据 整理与分析 2017.6-2017.6 撰写论文,论文答辩