1. 毕业设计（论文）的内容和要求

金纳米在化学分析和生物医学的应用领域成为后起之秀。

主要原因是由于金纳米颗粒形貌特殊，具有较大的比表面积；金纳米颗粒的毒性相对较低，具有良好的生物相容性；颗粒表面容易通过共价键、静电作用等分子间作用力被多种生物分子所修饰。

最近几年，金纳米颗粒被更广泛应用于临床免疫分析和生物传感器中。

2. 参考文献

[1]Wang J, Xue J, Wang J, Ye J, et al. Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes:detection of dopamine in the presence of ascorbic acid and thiols[J]. Adv. Funct. Mater., 2005, 15: 639-647. [2] Chang G, Zhang J D, Oyama M, et al. Silver-nanoparticel-attached indium tin oxide surfaces fabricated by a seed-mediated growth approach[J]. Phys.Chem. B., 2005, 109: 1204-1209. [3]Lin T H, Hung W H. Electrochemical Deposition of Gold Nanoparticles on a Glassy Carbon Electrode Modified with Sulfanilic Acid[J]. Journal of The Electrochemical Society, 2009, 156( 2): 45-50 . [4]Li L, Chen Q, Zhang Q, et al. Layered double hydroxide confined Au colloids: High performance catalysts for low temperature CO oxidation[J]. Catalysis Communications, 2012, 26: 15-18. [5]Quinn B M,Liljeroth P,Ruiz V,et al. Electrochemical Resolution of 15 Oxidation States for Monolayer Protected Gold Nanoparticle[J].Journal of the American Chemical Society,2003,125(22),6644-6645. [6]Chen S,Yang Y,Magnetoelectro chemistry of Gold Nanoparticle Quantized Capacitance Charging[J].Joumal of the American Chemical Society,2002,124(19),5280-5281. [7]Shi L, Chu Z, Liu Y, et al. Facile synthesis of hierarchically aloe-like gold micro/nanostructures for ultrasensitive DNA recognition[J]. Biosensors and Bioelectronics, 2013, 49: 184-191. [8]Karyakin A A, Puganova E A, Bolshakov I A, et al. Electrochemical sensor with record performance characteristics[J]. Angewandte Chemie International Edition, 2007, 46(40): 7678-7680.

3. 毕业设计（论文）进程安排

2.25-3.25 查阅文献并制定实验方案； 3.26-4.06 准备实验所需的药品和耗材； 4.07-4.19 按照实验方案进行实验； 4.20-4.30 材料表征； 5.3-5.20 实验条件优化及表征； 5.21-6.15 撰写毕业论文。