1. 毕业设计（论文）的内容和要求

1、熟悉基本的实验操作，理解实验的基本内容； 2、能做做到流利阅读文献，掌握文献内容； 3、熟练运用各种信息平台查阅相关信息； 4、了解当下有机化学方向中烯胺酮类化合物与含有三氟甲基的腙的反应的内容，了解它的背景以及意义； 5、熟悉并掌握其反应的机理。

2. 参考文献

Hideki Sugimoto.; Shuichi Nakamura.; Yoshihiko Watanabe, et al. Enantioselective hydrogen atom transfer to sulfonyl radicals controlled by selective coordination of a chiral Lewis acid to an enantiotopic sulfony oxygen. Asymmetry., 2003, 14, 3043-3055; [2]. Danqing Zheng.; Jiyao Yu.; Jie Wu. Generation of Sulfonyl Radicals from Aryldiazonium Tetrafluoroborates and Sulfur Dioxide: The Synthesis of 3-Sulfonated Coumarins. Angew. Chem., 2016, 128, 12104#8211;12108; [3]. Andrs Garcia-Dominguez.; Simona Mgller.; Cristina Nevado. Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals. Angew .Chem., 2017, 56, 9949#8211;9952; [4]. Sebastien Alazet.; Franck Le Vaillant.; Stefano Nicolai, et al. Divergent Access to (1,1)and (1,2)-Azidolactones from Alkenes using Hypervalent Iodine Reagents. Chem. Eur.J., 2017, 23,9501#8211;9504; [5]. Brett N. Hemric.; Kun Shen.; Qiu Wang. Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O#8209;Benzoylhydroxylamines. J. Am. Chem. Soc., 2016, 138, 5813#8722;5816; [6]. Delhine karila.; loic leman.; Robert H.Dodd. Copper-Catalyzed Iminoiodane-Mediated Aminolactonization of olefins:Application to the Synthesis of 5,5-Disubstituted Butyrolactones. Org. Lett., 2001, 21, 5830-5833; [7]. Yuzhen Gao.; Xueqin Li.; Weizhu Chen, et al. Copper-Catalyzed Phosphonation#8722;Annulation Approaches to the Synthesis of β#8209;Phosphonotetrahydrofurans Involving C#8722;P and C#8722;O Bonds Formation. J. Org. Chem., 2015, 80, 11398#8722;11406; [8]. Yuzhen Gao.; Xueqin Li.; Jian Xu, et al. Mn(OAc)3-mediated phosphonation#8211;lactonization of alkenoic acids: synthesis of phosphono-cbutyrolactones. Chem. Commun., 2015, 51, 1605#8212;1607; [9]. Hua Yang.; Xinhua Duan.; Jingfeng Zhao, et al. Transition-Metal-Free Tandem Radical Thiocyanooxygenation of Ole#64257;nic Amides: A New Route to SCN-Containing Heterocycles . Org. Lett., 2015, 17, 1998#8722;2001; [10]. Chunfa Xu.; Qilong Shen. Lewis Acid Mediate trifluoromethylthio Lactonization/Lactamization. Org. Lett., 2015, 17, 4561#8722;4563; [11]. Jian Xie.; Yue-Wei Wang.; Lian-Wen Qi, et al. Access to Aminated Saturated Oxygen Heterocycles via CopperCatalyzed Aminooxygenation of Alkenes. Org. Lett., 2017, 19, 1148#8722;1151; [12]. Zechen Zhu.; Jie Luo.; Xiaodan Zhao. Combination of Lewis Basic Selenium Catalysis and Redox Selenium Chemistry: Synthesis of Tri#64258;uoromethylthiolated Tertiary Alcohols with Alkenes. Org. Lett., 2017, 19, 4940#8722;4943; [13]. Tao Chen.; Thoms Jian Yao Foo.; Ying Yeung. Indole-Catalyzed Bromolactonization in Lipophilic Solvent: A Solid#8722; Liquid Phase Transfer Approach . ACS Catal., 2015, 5, 4751#8722;4755; [14]. Kumar Dilip Ashtekar.; Nastaran Salehi Marzijarani.; Arvind Jaganathan, et al. A New Tool To Guide Halofunctionalization Reactions: The Halenium Affinity (HalA) Scale. J. Am. Chem. Soc., 2014, 136, 13355#8722;13362; [15]. Wanxing Sha.; Wenzhong Zhang.; Shengyang Ni. Photoredox-Catalyzed Cascade Difluoralkylation and Intramolecular Cyclization for Construction of Fluorinated γ#8209;Butyrolactones. J. Org. Chem., 2017, 82, 9824#8722;9831;

3. 毕业设计（论文）进程安排

2017.12.1-2018.3.1 查阅资料，完成开题报告和任务书 2018.3.2-2018.3.10 确定方案，学习实验过程和操作 2018.3.11-2018.4.30 独立实验，合成产品并进行结构表征 2018.5.1-2018.5.30 数据整理，书写论文，制作PPT 2018.5.30- 修改论文并完成答辩