论文总字数：18429字

摘 要

镁及其合金具有非常良好的力学相容性、生物相容性能和可降解的性能以及良好的骨头诱导能力，作为现代新型的生物移植材料得到了广泛的关注。然而，镁合金耐腐蚀的能力较差，在氟离子特别多的人体生理环境中腐蚀速度很快，导致镁合金的性能下降，对骨头的保护作用大大的削弱。因此，研发开发新型可被我们控制分解速度镁合金医用材料，使镁合金在人体中的分解速度与骨组织愈合速度一样，在骨组织一直材料这个方面具有非常重要的意义。

HA（Hydroxyapatite，HA）因为它能够很好的与生物体相结合和很好的人体生物活性被用作最早的人体生物移植的医用材料，但是HA在人体的环境中溶解的速度较快，因此就会致使涂层的降解和分解这样就会影响移植材料的稳定性。而且我们的骨骼是一种缺钙型羟基磷灰石，与此同时有Mg，F和Zn等这些微量元素，加入一些微量元素来改善它的性能来达到临床上的性能。我们通过用F离子来取代氢氧根离子这样就可以改善它在溶液中的性质，能够使涂层较长时间的存在。

本实验研究采用溶胶凝胶的方法在AZ31镁合金表面制造出我们所需要的涂层，讨论研究出FHA涂层具备长期稳定性、与人体环境能够很好地相容和良好的人体生物相容性，符合了我们所需要的移植材料。

关键词: FHA,溶胶-凝胶，AZ31镁合金

Apatite and properties of sol-gel prepared fluorinated hydroxy biodegradable magnesium alloy material surface

ABSTRACT

Magnesium and magnesium alloys have good biocompatibility,mechanical properties of matching human bone and degradation in vivo, .However, the ability of magnesium alloy corrosion resistance is poor, particularly in the fluoride ion corrosion of human physiological environment quickly, resulting in decreased performance of magnesium alloy, the protective effect of bone greatly weakened. Therefore, the development of new research and development can be our control the decomposition rate of the magnesium alloy material for medical use, the magnesium alloy in the human body and the decomposition rate of bone healing, as very important in the bone tissues have been material in this respect.

Hydroxyapatite (HA, Ca10(PO4)6OH2) because it can be a good combination with the organism and good human biological activity is used as the first transplant of human biological material for medical use, but HA in the human environment dissolve faster, so it will cause the coating degradation and decomposition which would affect the stability of graft material.And our bones is a calcium hydroxyapatite, the same time there is Mg, F and Zn and other trace elements, trace elements added to improve its performance to achieve clinical performance. Using F ions substituted OH to reduce the solubility of HA, ensure long-term stability of the coating.

This study using sol-gel method for preparing a magnesium alloy surface coating, developed to discuss FHA coating with long-term stability can be a good compatibility and good biocompatibility with the human body environment, in line with what we need graft material.

Keywords: FHA, col-sol，AZ31 alloy

目 录

摘 要---------------------------------------------------------------------------------------- Ⅰ

ABSTRACT-------------------------------------------------------------------------------- Ⅱ

第一章 综述 (绪论) --------------------------------------------------------------------- 1

• 1. 课题背景------------------------------------------------------------------------- 1
  2. 镁合金的生物特点和前景分析--------------------------------------------- 1
  3. 镁合金医用领域的研究------------------------------------------------------ 2
  4. 羟基磷灰石的简介------------------------------------------------------------- 3
  5. 镁合金HA的制备------------------------------------------------------------- 3
  6. 论文的意义--------------------------------------------------------------------- 6

第二章 实验部分------------------------------------------------- 7

• 1. 实验材料及样本准备--------------------------------------------------------- 7
  2. 溶胶凝胶的制备------------------------------------------------------------ ---- 7
  3. 涂层样品的制备----------------------------------------------------------------- 7
  4. 涂层的性能测试----------------------------------------------------------------- 7
  5. 电化学测试----------------------------------------------------------------------- 7
  6. 浸渍腐蚀测试---------------------------------------------------------------------- 8
  7. 称重测试-------------------------------------------------------------------------- 8

第三章 结果与讨论----------------------------------------------- 8

• 1. 涂层的结构--------------------------------------------------------------------- 8
  2. 电化学腐蚀测试--------------------------------------------------------------- 10
  3. 浸泡腐蚀测试------------------------------------------------------------------ 11
  4. 重量损失测试------------------------------------------------------------------ 14

1. 结论与展望----------------------------------------------- 14

参考文献-------------------------------------------------------- 14

第一章 综述

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