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毕业论文网 > 任务书 > 化学化工与生命科学类 > 制药工程 > 正文

叶酸靶向的透明质酸-柔红霉素载药纳米粒的制备与研究任务书

 2020-02-18 17:39:15  

1. 毕业设计(论文)主要内容:

1. 以柔红霉素为模型药物,以透明质酸为载体,自组装成纳米粒,得到高分子载药纳米粒。

2. 对高分子前药进行核磁共振氢谱,紫外,红外表征。

3. 完成纳米粒的制备及对纳米粒进行激光粒度仪的表征。

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2. 毕业设计(论文)主要任务及要求

1、查阅不少于20篇的相关资料,其中英文文献不少于2篇,完成开题报告。

2、完成高分子前药的结构表征及其纳米粒的制备与研究。

3、完成不少于5000字的英文文献翻译。

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3. 毕业设计(论文)完成任务的计划与安排

第1-2周:查阅相关文献资料,确定研究方案,完成开题报告。

第3-5周:完成高分子前药的制备与表征
第6-10周:完成纳米粒的制备与表征
第11-12周:完成纳米粒的释药性能研究
第13-14周:完成并修改毕业论文。

第15 周:准备论文答辩。

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4. 主要参考文献

[1]Zhang B, Chang B, Sun T. Synthesis and Study of Hypoxia-Responsive Micelles Based on Hyaluronic Acid[J]. Acta Chimica Sinica, 2018, 76(1):35.
[2]Lee H J, Bae Y. Pharmaceutical differences between block copolymer self-assembled and cross-linked nanoassemblies as carriers for tunable drug release.[J]. Pharm Res, 2013, 30(2):478-488.
[3]Cao J, Zheng H, Hu R, et al. pH-Responsive Nanoparticles Based on Covalently Grafted Conjugates of Carboxymethyl Chitosan and Daunorubicin for the Delivery of Anti-Cancer Drugs.[J]. Journal of Biomedical Nanotechnology, 2017.
[4]Hu R, Zheng H, Cao J, et al. Self-Assembled Hyaluronic Acid Nanoparticles for pH-Sensitive Release of Doxorubicin: Synthesis and In Vitro Characterization[J]. Journal of Biomedical Nanotechnology, 2017, 13(9):1058-1068.
[5]Liao J, Zheng H, Hu R, et al. Hyaluronan Based Tumor-Targeting and pH-Responsive Shell Cross-Linkable Nanoparticles for the Controlled Release of Doxorubicin[J]. Journal of Biomedical Nanotechnology, 2018.
[6]Zhang W, Mu H, Zhang A, et al. A decrease in moisture absorption-retention capacity of N-deacetylation of hyaluronic acid[J]. Glycoconj J, 2013, 30(6):577-583.
[7]Jeannot V, Gauche C, Mazzaferro S, et al. Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer[J]. Journal of Controlled Release Official Journal of the Controlled Release Society, 2018, 275.
[8]Zamboni F, Vieira S, Rui L R, et al. The Potential of Hyaluronic acid in Immunoprotection and Immunomodulation: Chemistry, Processing and Function[J]. Progress in Materials Science, 2018, 97.
[9]Li W P, Su C H, Chang Y C, et al. Ultrasound-Induced Reactive Oxygen Species-Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome[J]. Acs Nano, 2015, 10(2).
[10]Hu R, Zheng H, Cao J, et al. Synthesis and In Vitro Characterization of Carboxymethyl Chitosan-CBA-Doxorubicin Conjugate Nanoparticles as pH-Sensitive Drug Delivery Systems[J]. Journal of Biomedical Nanotechnology, 2017, 13(9):1097-1105.
[11]Ghasemi A, Jafari S, Saeidi J, et al. Synthesis and characterization of polyglycerol coated superparamagnetic iron oxide nanoparticles and cytotoxicity evaluation on normal human cell lines[J]. Colloids amp; Surfaces A Physicochemical amp; Engineering Aspects, 2018.
[12]Wang G, Zhang X, Skallberg A, et al. One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging[J]. Journal of Orthopaedic Translation, 2014, 2(4):231-231.
[13]Alexander, P., G. Kucera and T.S. Pardee, Improving nucleoside analogs via lipid conjugation: Is fatter any better? Critical Reviews in Oncology/Hematology, 2016.
[14]Mitra, A.K., et al., Novel delivery approaches for cancer therapeutics. Journal of Controlled Release, 2015. 219: p. 248-268.
[15]Videira, M., R.L. Reis and M.A. Brito, Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014. 1846(2): p. 312-325.
[16]Bhushan, S., et al., The augmented anticancer potential of AP9-cd loaded solid lipid nanoparticles in human leukemia Molt-4 cells and experimental tumor. Chemico-Biological Interactions, 2016. 244: p. 84-93.
[17]DiPersio, J.F., et al., Oral Debio1143 (AT406), an Antagonist of Inhibitor of Apoptosis Proteins, Combined With Daunorubicin and Cytarabine in Patients With Poor-Risk Acute Myeloid Leukemia—Results of a Phase I Dose-Escalation Study. Clinical Lymphoma Myeloma and Leukemia, 2015. 15(7): p. 443-449.
[18]Kakavandi B, Takdastan A, Jaafarzadeh N, et al. Application of Fe 3 O 4 @C catalyzing heterogeneous UV-Fenton system for tetracycline removal with a focus on optimization by a response surface method[J]. Journal of Photochemistry amp; Photobiology A Chemistry, 2016, 314(1):178-188.
[19]Panic, G., et al., Repurposing drugs for the treatment and control of helminth infections. International Journal for Parasitology: Drugs and Drug Resistance, 2014. 4(3): p. 185-200.
[20]di Masi, A., et al., Retinoic acid receptors: From molecular mechanisms to cancer therapy. Molecular Aspects of Medicine, 2015. 41: p. 1-115.
[21]Hu J J, Lei Q, Peng M Y, et al. A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem.[J]. Biomaterials, 2017, 128:136.
[22]Wang X Q, Gao F, Zhang X Z. Initiator Loaded Gold Nanocages as Light-Induced Free Radical Generator for Cancer Therapy.[J]. Angewandte Chemie, 2017, 129(31).
[23]Shen L, Li B, Qiao Y. Fe3O4Nanoparticles in Targeted Drug/Gene Delivery Systems[J]. Materials, 2018, 11(2):324.
[24]Liu J, Liu G, Yuan C, et al. Fe3O4/ZnFe2O4 micro/nanostructures and their heterogeneous efficient Fenton-like visible-light photocatalysis process[J]. New Journal of Chemistry, 2018, 42(5).
[25]Zhang Y, Wu K, Sun H, et al. Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin.[J]. Acs Applied Materials amp; Interfaces, 2018, 10(2).

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