1. 毕业设计（论文）的内容和要求

分析、收集一类免疫球蛋白β三明治结构的突变的热力学与动力学数据，构建β蛋白变构的约化矩阵，开发关联突变的矩阵表示模型。

2. 参考文献

1. Bork P, Holm L, Sander C: The immunoglobulin fold. Structural classification, sequence patterns and common core. J Mol Biol 1994, 242(4):309-320. 2. Halaby DM, Poupon A, Mornon JP: The immunoglobulin fold family: sequence analysis and 3D structure comparisons. Protein Eng 1999, 12(7):563-571 3. Clarke J, Cota E, Fowler SB, Hamill SJ: Folding studies of immunoglobulin-like beta-sandwich proteins suggest that they share a common folding pathway. Structure 1999, 7(9):1145-1153. 4. Pucci F, Bourgeas R, Rooman M: High-quality Thermodynamic Data on the Stability Changes of Proteins Upon Single-site Mutations. J Phys Chem Ref Data 2016, 45(2). 5. Harris LJ, Larson SB, Hasel KW, McPherson A: Refined structure of an intact IgG2a monoclonal antibody. Biochemistry-Us 1997, 36(7):1581-1597. 6. Bhavaraju M, Hansmann UHE: Effect of single point mutations in a form of systemic amyloidosis. Protein Sci 2015, 24(9):1451-1462.

3. 毕业设计（论文）进程安排

2月下旬-3月中旬：文献检索、数据准备、模型准备 3月中旬--5月中旬：数据模拟,统计分析，建模。

5月中旬--六月上旬：论文写作、答辩。