1. 毕业设计（论文）主要内容：

1.以柔红霉素为模型药物，以raft聚合制备的pdao共聚物为载体，将柔红霉素以化学键键合的形

式连接在聚合物载体上。

2. 毕业设计（论文）主要任务及要求

1、查阅不少于20篇的相关资料，其中英文文献不少于2篇，完成开题报告。

2、完成pdao聚合物-柔红霉素高分子前药的结构表征及其纳米粒的制备与研究。

3、完成不少于5000字的英文文献翻译。

3. 毕业设计（论文）完成任务的计划与安排

第1-2周：查阅相关文献资料，确定研究方案，完成开题报告。

第1－2周：查阅相关文献资料，确定研究方案，完成开题报告。

第3-5周：完成高分子前药的制备与表征

4. 主要参考文献

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2. L. W. Tan, B. Y. Ma, QianZhao, LanZhang, L. J. Chen, J. R. Peng, and Z. Y. Qian, Toxicity Evaluation and Anti-Tumor Study of Docetaxel Loaded mPEG-Polyester Micelles for Breast Cancer Therapy. J. Biomed. Nanotechnol. 13, 393 (2017).
3. J. Xue, Z. Zhao, L. Zhang, L. Xue, S. Shen, Y. Wen, Z. Wei, L. Wang, L. Kong, and H. Sun, Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nat. Nanotechnol. 12, 692 (2017).
4. S. Chandra, S. Nigam, and D. Bahadur, Combining unique properties of dendrimers and magnetic nanoparticles towards cancer theranostics. J. Biomed. Nanotechnol. 10, 32 (2014).
5. E. Nance, F. Zhang, M. K. Mishra, Z. Zhang, S. P. Kambhampati, R. M. Kannan, and S. Kannan, Nanoscale effects in dendrimer-mediated targeting of neuroinflammation. Biomaterials 101, 96 (2016).
6. D. Liu, S. Tang, G. Wang, M. Li, X. Liu, H. Tao, Y. Ren, C. Jiang, H. Peng, and M. Lian, The Influences of Dynamic Transport of GLUT1 on the Distribution of Mannosylated Liposomes in Transient Ischemia Reperfusion Mice Brain. J. Biomed. Nanotechnol. 13, 638 (2017).
7. F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, and K. Kataoka, Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90, 62 (2016).
8. H. Yang, M. Liu, H. Jiang, Y. Zeng, L. Jin, T. Luan, Y. Deng, N. He, G. Zhang, and X. Zeng, Copy Number Variation Analysis Based on Gold Magnetic Nanoparticles and Fluorescence Multiplex Ligation-Dependent Probe Amplification. J. Biomed. Nanotechnol. 13, 655 (2017).
9. M. S. Karbownik, and J. Z. Nowak, Hyaluronan: towards novel anti-cancer therapeutics. Pharmacol. Rep. 65, 1056 (2013).
10. G. Tripodo, A. Trapani, M. L. Torre, G. Giammona, G. Trapani, and D. Mandracchia, Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges. Eur. J. Pharm. Biopharm. 97, 400 (2015).