1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，elsevier、ncbi电子期刊，springer link全文电子期刊，pubmed等检索资源上查阅关于类胡萝卜素、耐辐射奇球菌等方面的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] Sankari M, Rao PR, Hemachandran H, Pullela PK, George PDC, Tayubi IA, Subramanian B, Gothandam KM, Singh P, Ramamoorthy S (2017) Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches. Journal of Biotechnology 266, 89-101. [2] Yabuzaki J (2017) Carotenoids Database: structures, chemical fingerprints and distribution among organisms. Database the Journal of Biological Databases Curation 2017. [3] Tian B, Hua Y (2010) Carotenoid biosynthesis in extremophilic Deinococcus-Thermus bacteria. Trends in Microbiology 18, 512-520. [4] Saini RK, Keum YS (2017) Progress in Microbial Carotenoids Production. Indian Journal of Microbiology 57, 1-2. [5] Mukherjee T, Bose S, Mukhopadhyay SK (2017) Antioxidant properties of the carotenoid extracts of three Deinococcus#8211;Thermus phylum bacteria, Meiothermus sp. strains RP and TP and Thermus sp. strain YY from Paniphala hot spring, India. Nutrire 42, 7. [6] Slade D, Radman M (2011) Oxidative stress resistance in Deinococcus radiodurans. Microbiology and molecular biology reviews 75, 133-191. [7] Tian B, Sun Z, Shen S, Wang H, Jiao J, Wang L, Hu Y, Hua Y (2009) Effects of carotenoids from Deinococcus radiodurans on protein oxidation. Letters in Applied Microbiology 49, 689-694. [8] Cheng J, Zhang Z, Zheng Z, Lv G, Wang L, Tian B, Hua Y (2014) Antioxidative and Hepatoprotective Activities of Deinoxanthin-Rich Extract from Deinococcus radiodurans R1 against Carbon Tetrachloride-Induced Liver Injury in Mice. Tropical Journal of Pharmaceutical Research 13, 581. [9] Bornot J, Molinajouve C, Uribelarrea JL, Gorret N (2014) Growth of the extremophilic Deinococcus geothermalis DSM 11302 using co-substrate fed-batch culture. Applied Microbiology Biotechnology 98, 1281-1290. [10] He Y (2009) High cell density production of Deinococcus radiodurans under optimized conditions. Journal of Industrial Microbiology Biotechnology 36, 539. [11] Wu Y (2005) Study on the Extraction Methods of Carotenoids from Fermented Liquor of Deinococcus Radiodurans. Journal of Chinese Institute of Food Science Technology. [12] Hu Y, Xu X, Song P, Jiang L, Zhang Z, Huang H (2013) Draft Genome Sequence of Deinococcus xibeiensis R13, a New Carotenoid-Producing Strain. Genome Announcements 1. [13] Kim J, Kong MK, Sang YL, Lee PC (2010) Carbon sources-dependent carotenoid production in metabolically engineered Escherichia coli. World Journal of Microbiology Biotechnology 26, 2231-2239. [14] Silva CM, De MdBT, Kalil SJ, de Medeiros JF, Burkert (2016) Raw Glycerol and Parboiled Rice Effluent for Carotenoid Production: Effect of the Composition of Culture Medium#8232;and Initial pH. Food Technology Biotechnology 54, 489. [15] Bhosale P (2004) Environmental and cultural stimulants in the production of carotenoids from microorganisms. Applied Microbiology Biotechnology 63, 351-361.

3. 毕业设计（论文）进程安排

2018.12.20-2019.1.9 文献查询和资料阅读 2019.1.9-2019.1.16 研究方案制定和开题报告写作 2019.1.16-2019.2.25 实践内容的准备 2019.2.25-2019.5.10 实践 2019.5.10-2019.5.15 实践内容处理与结果分析 2019.5.16-2019.6.1 毕业论文书写